After a dramatic jailbreak at a top secret prison, the planet's most dangerous supervillains are on the loose! Luckily Murph Cooper and the Super Zeroes are on hand to chase them down. But though they manage to bring in a whole host of baddies, they can't find their nemesis Magpie anywhere.

Little do they know that he is close by, and he's linked up with another old enemy. The super smarmy Nicholas Knox is back! Together, they've developed a dastardly machine that can GIVE people superpowers! In the wrong hands it has the potential to bring about the end of the world of Heroes as we know it . and it just happens to be in the wrongest hands of all!